In-cell architecture of the mitochondrial respiratory chain.

• Tác giả: Benjamin D Engel, Ron Kelley, Sagar Khavnekar, Abhay Kotecha, Lorenz Lamm, Martin Obr, Ricardo D Righetto, Thalia Salinas-Giegé, Florent Waltz, Xianjun Zhang
• Ngôn ngữ: eng
• Thông tin xuất bản: United States : Science (New York, N.Y.) , 2025
• Bộ sưu tập: NCBI
• ID: 726156

Tóm tắt

Mitochondria regenerate adenosine triphosphate (ATP) through oxidative phosphorylation. This process is carried out by five membrane-bound complexes collectively known as the respiratory chain, working in concert to transfer electrons and pump protons. The precise organization of these complexes in native cells is debated. We used in situ cryo-electron tomography to visualize the native structures and organization of several major mitochondrial complexes in