Associations of self-identified race and ethnicity and genetic ancestry with mortality among cancer survivors.

• Tác giả: Amy Berrington De Gonzalez, Derek W Brown, Ian D Buller, Neal D Freedman, Wen-Yi Huang, Rena R Jones, Peter Kraft, Maria Teresa Landi, Mitchell J Machiela, Timiya S Nolan, Jaimie Z Shing, Naoise Synnott, Jacqueline B Vo, Faustine Williams
• Ngôn ngữ: eng
• Ký hiệu phân loại: 745.56 Metals
• Thông tin xuất bản: United States : Journal of the National Cancer Institute , 2025
• Bộ sưu tập: NCBI
• ID: 726180

Tóm tắt

 Self-identified race and ethnicity (SIRE) and genetic ancestry (GA) are potentially associated with disparities in health outcomes
  however, independent effects of SIRE and GA on mortality in cancer survivors including when adjusting for multiple risk factors are understudied. Among 23,445 cancer survivors in the Prostate, Lung, Colorectal, and Ovarian Screening Trial, SIRE was associated with mortality among prostate, colorectal, lung, ovarian, and breast cancer survivors
  GA was associated with mortality among prostate, colorectal, and breast cancer survivors. Associations were strong when adjusting for age at cancer diagnosis, sex, and tumor characteristics, but attenuated when adjusting for individual-level factors and population-level socioeconomic status. For example, mortality risk was higher among Black vs White prostate cancer survivors and African GA vs European GA, but associations were attenuated after multilevel adjustment. Results suggest SIRE and GA do not solely reflect biologic variation
  rather, social factors may drive mortality differences by SIRE and GA.