Computational Approaches for Predicting Drug Interactions with Human Organic Anion Transporter 4 (OAT4).

• Tác giả: Nathan J Cherrington, Sean Ekins, Joshua S Harris, Thomas R Lane, Lucy Martinez-Guerrero, Fabio Urbina, Patricia A Vignaux, Stephen H Wright
• Ngôn ngữ: eng
• Ký hiệu phân loại: 616.9223 Other diseases
• Thông tin xuất bản: United States : Molecular pharmaceutics , 2025
• Bộ sưu tập: NCBI
• ID: 726253

Tóm tắt

Human Organic Anion Transporter 4 (OAT4) is predominantly expressed in the kidneys, particularly in the apical membrane of the proximal tubule cells. This transporter is involved in the renal handling of endogenous and exogenous organic anions (OAs), making it an important transporter for drug-drug interactions (DDIs). To better understand OAT4-compound interactions, we generated single concentration (25 μM)