OBJECTIVES: Extended reality (XR) applications are gaining support as a method of reducing anxieties about medical treatments and conditions
however, their impacts on health service inequalities remain underresearched. We therefore undertook a synthesis of evidence relating to the equity implications of these types of interventions. MATERIALS AND METHODS: Searches of MEDLINE, Embase, APA PsycINFO, and Epistemonikos were conducted in May 2023 to identify reviews of patient-directed XR interventions for health and procedural anxiety. Equity-relevant data were extracted from records (n = 56) that met these criteria, and from individual trials (n = 63) evaluated within 5 priority reviews. Analyses deductively categorized data into salient situation- and technology-related mechanisms, which were then developed into a novel implementation-focused framework. RESULTS: Analyses highlighted various mechanisms that impact on the availability, accessibility, and/or acceptability of services aiming to reduce patient health and procedural anxieties. On one hand, results showed that XR solutions offer unique opportunities for addressing health inequities, especially those concerning transport, cost, or mobility barriers. At the same time, however, these interventions can accelerate areas of inequity or even engender additional disparities. DISCUSSION: Our "double jeopardy, common impact" framework outlines unique pathways through which XR could help address health disparities, but also accelerate or even generate inequity across different systems, communities, and individuals. This framework can be used to guide prospective interventions and assessments. CONCLUSION: Despite growing positive assertions about XR's capabilities for managing patient anxieties, we emphasize the need for taking a cautious, inclusive approach to implementation in future programs.