Diabetes Mellitus and APOL1 Genotype Increase the Risk for Chronic Kidney Disease Progression in Sickle Cell Disease.

• Tác giả: Marwah W Farooqui, Victor R Gordeuk, Jin Han, Zalaya K Ivy, Brian T Layden, Robert Molokie, Franklin Njoku, Insia Rizvi, Santosh L Saraf, Anand Srivastava, Ryan Sun, Joseph L Zapater
• Ngôn ngữ: eng
• Ký hiệu phân loại: 611.316 Salivary glands
• Thông tin xuất bản: United States : Blood , 2025
• Bộ sưu tập: NCBI
• ID: 726374

Tóm tắt

We observed diabetes mellitus (DM) in 9.3% of adults with sickle cell disease (SCD) and DM predicted a 7-fold greater risk for chronic kidney disease progression adjusting for high-risk APOL1. Our results emphasize the clinical significance of DM in SCD.