ApoE ε4-dependent Alteration of CXCR3

• Tác giả: Mei Chen, Sarah Daley, Yuyang Han, Martin Hemberg, Dan Hu, Xuyang Li, Peter Morin, Howard L Weiner, Weiming Xia
• Ngôn ngữ: eng
• Thông tin xuất bản: United States : Journal of Alzheimer's disease : JAD , 2025
• Bộ sưu tập: NCBI
• ID: 726408

Tóm tắt

BackgroundRecent findings indicate a correlation between the peripheral adaptive immune system and neuroinflammation in Alzheimer's disease (AD).ObjectiveTo characterize the composition of adaptive immune cells in the peripheral blood of AD patients.MethodsWe utilized single-cell mass cytometry (CyTOF) to profile peripheral blood mononuclear cells (PBMCs). Concurrently, we assessed the concentration of proteins associated with AD and neuroinflammation in the plasma of the same subjects.ResultsWe found that the abundance of proinflammatory CXCR3