Widespread antibiotic heterotolerance in bacteria remains undetected by resistance assays.

• Tác giả: Lieze Agten, Paul Cos, Linda De Vooght, Nele Geerts, Jan Michiels, Sang Nguyen, Philip Ruelens, Bram Van den Bergh, Laurence Van Moll, Laure Verstraete, Natalie Verstraeten
• Ngôn ngữ: eng
• Ký hiệu phân loại: 332.34 Pawnshops
• Thông tin xuất bản: Scotland : Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy , 2025
• Bộ sưu tập: NCBI
• ID: 726586

Tóm tắt

 Despite global efforts, antimicrobial resistance persists. Mechanisms like heterotolerance further undermine antibiotic effectiveness. Testing >
  1000 clinical strains revealed widespread heterotolerance largely missed by conventional MIC-based diagnostics. Since AMR alone does not predict treatment success, new tests and strategies incorporating tolerance data are urgently needed to significantly improve patient outcomes.