Biogas production through anaerobic digestion offers a promising alternative to address climate change. In this study, the ADM1 model was used to simulate the digestion of four different substrates: a mixture of rye and maize silage, a mixture of cow slurry and maize silage, cow slurry alone, and food waste. Furthermore, the determination of total solids (TS) content was integrated into the model. Based on experimental data from 5 L Continuous Stirred Tank Reactors (CSTR), ADM1 model parameters were calibrated for each substrate, primarily differing in hydrolysis and inhibition constants. These parameters, along with two additional sets of parameters from the literature, were subsequently applied in simulations to assess methane productivity, yield, and TS under increasing organic loading rates (OLR) for each substrate. Among the substrates, food waste showed the highest productivity, yield, and solids removal, while rye and maize silage substrate was the most unstable, with system failure at the lowest OLR (7 kgVS.m