Transgenerational inheritance of mitochondrial hormetic oxidative stress mediated by histone H3K4me3 and H3K27me3 modifications.

• Tác giả: Wenyu Dai, Xiaoxia Fu, Chenyang He, Yimin Li, Zhenhuan Luo, Qin-Li Wan, Chongyang Wang, Dan Wu, Jing Yang, Xiaoyang Yue
• Ngôn ngữ: eng
• Ký hiệu phân loại: 133.594 Types or schools of astrology originating in or associated with a
• Thông tin xuất bản: Netherlands : Redox biology , 2025
• Bộ sưu tập: NCBI
• ID: 726705

Tóm tắt

 Mitochondrial hormetic oxidative stress (mtHOS) is crucial in physiology and disease
  however, its effects on epigenetic inheritance and organism fitness across generations remains elusive. Utilizing the C. elegans as a model, we elucidate that parental exposure to mtHOS not only elicits a lifespan extension in the exposed individuals but also confers this longevity advantage to the progeny through the transgenerational epigenetic inheritance (TEI) mechanism. This transgenerational transmission of lifespan prolongation depends on the activation of the UPR