Electron dose optimisation based on tumour thickness and shape for photon multi-leaf collimated megavoltage electrons.

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Tác giả: F C P du Plessis, D van Eeden

Ngôn ngữ: eng

Ký hiệu phân loại: 781.546 *Television music

Thông tin xuất bản: England : Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 726776

This study developed an optimisation method that considers tumour thickness for modulated electron radiation treatment (MERT) at a treatment distance of 60 cm. It comprises forming a tumour bed matrix from which a transformed tumour bed matrix is derived. From the discrete tumour bed depth data, electron beam segments were extracted, which were further decomposed into sub-beams. The EGSnrc-based Monte Carlo codes BEAMnrc and DOSXYZnrc were used to model a linear accelerator and to score 3-D dose data for various field sizes (sub-beams) in a water phantom model. The use of different energy and intensity-modulated electron sub-beams to irradiate a parotid lesion was investigated by applying the developed optimisation method. After each sub-beam energy was determined, a least square cost function minimisation was invoked to deliver a minimum dose to the tumour volume and produce a set of weight factors synonymous with beam intensity modulation. This study describes a technique to derive apertures and suitable sub-beam energy to provide a method for planning a robust MERT technique that yields dose-covering results and dose spread within the tumour that aligns with literature studies.
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