Genetic protection from type 1 diabetes resulting from accelerated insulin mRNA decay.

• Tác giả: John S Kaddis, Kevin V Morris, Denis O'Meally, Bart O Roep, Tristan A Scott, René van Tienhoven, John C Williams, Arnaud Zaldumbide
• Ngôn ngữ: eng
• Ký hiệu phân loại: 617.057 Endoscopic surgery
• Thông tin xuất bản: United States : Cell , 2025
• Bộ sưu tập: NCBI
• ID: 726878

Tóm tắt

 Insulin gene (INS) variation and beta-cell stress are associated with the risk of development of type 1 diabetes (T1D) and autoimmunity against insulin. The unfolded protein response alleviating endoplasmic reticulum (ER) stress involves activation of inositol-requiring enzyme 1α (IRE1α) that impedes translation by mRNA decay. We discover that the IRE1α digestion motif is present in insulin mRNA carrying SNP rs3842752 (G>
 A). This SNP in the 3' untranslated region of INS associates with protection from T1D (INS