Defective gating of the Sec61 translocon results in reorganisation of the actin cytoskeleton and perturbed formation of the actomyosin contractile ring.

• Tác giả: Danielle E Dye, Carl J Mousley, Robert F L Steuart, Lee V Thomasson, Christopher M Witham
• Ngôn ngữ: eng
• Thông tin xuất bản: Netherlands : Biochimica et biophysica acta. Molecular cell research , 2025
• Bộ sưu tập: NCBI
• ID: 727022

Tóm tắt

The Sec61 complex sits between the distinct environments of the cytosol and the ER lumen and it's appropriate gating is essential to prevent the deleterious flux of molecules and ions between them. Using the sss1-7 mutant we show that actin dynamics is grossly perturbed when translocon gating is defective. Importantly, normal actin morphology is restored when sss1-7 translocon gating defects are suppressed or when these cells are treated with cell-permeable Ca