TRPV4 in cerebral small vessel disease: A key interacting partner.

• Tác giả: Sébastien Foulquier, Sara M P Lambrichts, Robert J van Oostenbrugge
• Ngôn ngữ: eng
• Thông tin xuất bản: United States : Vascular pharmacology , 2025
• Bộ sưu tập: NCBI
• ID: 727028

Tóm tắt

Cerebral small vessel disease (cSVD) is a major cause of vascular cognitive impairment and dementia. The underlying disease mechanisms are centered around the dysfunction of the neurovascular unit and include an impairment of the blood-brain barrier (BBB) permeability, a decreased cerebrovascular reactivity and cerebral hypoperfusion. The cells composing the neurovascular unit express a wide variety of mechanosensitive ion channels that are relevant for these processes. Recent research has increasingly focused on the mechanobiology of cerebral microvessels with recent evidence pointing towards a significant role of transient receptor potential vanilloid 4 (TRPV4). This Ca