Development of an efficient chimeric trifunctional xylanase/glucanase/feruloyl esterase and its application in the bioconversion of corn stover into fermentable sugars.

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Tác giả: Lixin He, Shuangcheng Liang, Minghua Lin, Xiaoqin Lin, Yizhou Liu, Kui Wang, Sidi Wang, Wenke Xiong, Ruoting Zhan, Ying Zhang

Ngôn ngữ: eng

Ký hiệu phân loại:

Thông tin xuất bản: Netherlands : International journal of biological macromolecules , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 727097

Multifunctional enzymes have the potential to enhance hydrolytic efficiency and reduce enzyme cost. In this study, by optimizing linker peptide identity and the order of fusion partners, an efficient trifunctional xylanase/glucanase/feruloyl esterase, named Xyn(Glu)A/FaeB-L1, was obtained through associating the Bacillus bifunctional xylanase/glucanase Xyn(Glu)A with its cognate feruloyl esterase FaeB using a flexible linker peptide (L1). In comparison to the parental enzymes, Xyn(Glu)A/FaeB-L1 displayed similar pH optima for enzyme activity, shifting no more than a single unit. However, the optimal reaction temperature was 5-10 °C lower than that of the parental enzymes. Intriguingly, its catalytic efficiencies (k
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