Tanycyte proliferation and migration through the sonic hedgehog pathway restores hypothalamic function after ischemic injury.

• Tác giả: Mengjie Che, Rongjun Chen, Zhanpeng Feng, Haodong Gong, Kai Li, Xufan Ling, Yichao Ou, Junxiang Peng, Songtao Qi, Qiancheng Song, Hai Wang, Xingqin Wang, Yihan Wang, Zijing Wang, Guangsen Wu, Zhiwei Xiong, Mingfeng Zhou
• Ngôn ngữ: eng
• Thông tin xuất bản: United States : Free radical biology & medicine , 2025
• Bộ sưu tập: NCBI
• ID: 727098

Tóm tắt

Tanycytes, a distinct type of glial cell within the hypothalamus, will be investigated in this study to elucidate the intrinsic mechanisms by which they facilitate the restoration of hypothalamic function. We injected endothelin 1 (ET-1) into the third ventricle to establish an ischemic hypothalamic injury model. Nestin CreER