Astrocytes control cocaine-induced synaptic plasticity and reward through the matricellular protein hevin.

• Tác giả: Augusto Anesio, Catalina Betancur, Fernando Bezerra, Paula Bianchi, Antony A Boucard, Fabio C Cruz, Andrew L Eagle, Amaia M Erdozain, Gustavo J D Fernandes, Clara Franco, Sophie Gautron, Carole Gruszczynski, Nicolas Heck, Dongdong Li, Franck Louis, Steeve Maldera, Raphaële Mongrédien, Marie-Laure Niépon, Cuong Pham, Séverine Robert, Alfred J Robison, Vincent Vialou, Adèle Vilette
• Ngôn ngữ: eng
• Thông tin xuất bản: United States : Biological psychiatry , 2025
• Bộ sưu tập: NCBI
• ID: 727216

Tóm tắt

BACKGROUND: Astrocytes in the nucleus accumbens (NAc) play a dynamic role in regulating synaptic plasticity induced by drugs of abuse through modulation of glutamatergic neurotransmission. Astrocyte-secreted factors may also contribute to the reprogramming of brain circuitry leading to drug-seeking behavior. Here we investigated the role of astrocyte Ca METHODS: Ca RESULTS: Cocaine increased the amplitude of Ca CONCLUSIONS: These findings reveal a fine-tuning by cocaine of in vivo Ca