Dansylated Amino Acid-Modified Long-Acting PSMA Derivatives

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Tác giả: Xiaoyuan Chen, Huifeng Guo, Vivianne Jakobsson, Xinyi Li, Xiaomin Liu, Yatong Qin, Huaxiang Shen, Jiarou Wang, Xuejun Wen, Hehe Xiong, Hongzhang Yang, Fantian Zeng, Heng Zhang, Jingjing Zhang, Tianzhi Zhao, Zijian Zhou

Ngôn ngữ: eng

Ký hiệu phân loại: 599.367 *Cynomys (Prairie dogs)

Thông tin xuất bản: United States : Journal of nuclear medicine : official publication, Society of Nuclear Medicine , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 727298

Prostate-specific membrane antigen (PSMA)-targeted radiopharmaceutical therapy has demonstrated promising potential for treating metastatic castration-resistant prostate cancer. Recently, albumin-binding motif-modified PSMA radioligands with prolonged blood circulation were developed to improve tumor uptake and therapeutic effectiveness, properties which, however, were associated with an increased risk of bone marrow toxicity. This study presents new PSMA-targeted radioligands incorporating dansylated amino acids as relatively weak and preferable albumin binders to achieve a fine balance between increased tumor accumulation, safety, and diagnostic efficacy, facilitating a unified approach to theranostics within a single molecular framework.
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