Synthesis and Preclinical Evaluation of Peptide Dimer-Based PET Tracers for Imaging VEGFR-2 Expression in Tumors.

• Tác giả: Ran Bingyu, Xu Hao, Ma Jie, Shang Jingjie, Hu Kuan, Hou Lu, Wang Lu, Cai Qijun, Zhang Siqi, Ye Weijian, He Wenjun, Cao Xiaoling, Chen Xueyao, Li Yingxin, Cheng Yong, Jiang Yuanfang
• Ngôn ngữ: eng
• Ký hiệu phân loại: 978.02 1800–1899
• Thông tin xuất bản: England : Journal of labelled compounds & radiopharmaceuticals , 2025
• Bộ sưu tập: NCBI
• ID: 727301

Tóm tắt

The vascular endothelial growth factor A (VEGF-A)/VEGF receptor 2 (VEGFR-2) signaling pathway is pivotal in regulating angiogenesis. We have synthesized a linear peptide-based VEGFR-2-targeted positron emission tomography (PET) tracer, but its target affinity and in vivo stability need further improvement. In this study, we developed two novel