Photodynamic therapy (PDT) is a clinically approved noninvasive treatment for cancer that employs a photosensitizer (PS) to generate cytotoxic reactive singlet oxygen (ROS) species that precisely destroy cancer cells at the targeted tumor sites. There is growing interest in the development of innovative photosensitizing agents and advanced delivery methods, offering superior phototherapeutic performance. The delivery of PS is a challenging task in PDT in regard to the high hydrophobicity of the PS molecule. To address this challenge, the incorporation of heavy-atom-free PS (HAF-PS) in effective drug delivery carriers is promising for PDT improvement. Herein, we propose a strategy to encapsulate the HAF-PS from the perylenediimide (PDI) family in the oily core of lipid nanocapsules (LNCs). The resulting HAF-PS-loaded LNCs formulations have the advantage to efficiently generate singlet oxygen (