SCM-198 Inhibits EMS Development by Reversing Decreased Proportions of IFN-γ

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Tác giả: Meirong Du, Yue Li, Yunyun Li, Yikong Lin, Yewei Lu, Beihua Wang, Xiaolin Wang, Yizhun Zhu

Ngôn ngữ: eng

Ký hiệu phân loại:

Thông tin xuất bản: United States : Reproductive sciences (Thousand Oaks, Calif.) , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 727726

Endometriosis is a common gynecological disease that causes severe pain and infertility. However, the available treatments for EMS are limited. SCM-198, a synthetic form of leonurine, possesses various abilities, including anti-inflammatory, immunomodulatory, antioxidant, anti-fibrotic, and anti-proliferative effects. Previous studies have shown that SCM-198 can inhibit the growth of ectopic lesions, but the specific mechanism remains unknown. The results of our studies indicate that SCM-198 significantly suppresses the endometriotic growth of EMS mice. Enrichment analysis of RNA-seq indicates that SCM-198 is involved in T cell differentiation, activation, cytokine production, stimulation of chemotaxis, and migration. Flow cytometry reveals that SCM-198 reverses the decreased proportions of IFN-γ + T cells and CCR5 + T cells in ectopic lesions. RNA-seq analysis shows that SCM-198 enhances the expression of CCL5 in the ectopic lesions, and western blot is conducted to verify this conclusion both in vivo and in vitro. These findings demonstrate that SCM-198 reverses the decreased proportions of IFN-γ + T cells and CCR5 + T cells, alleviating the growth of mouse ectopic lesions, and the changes in CCR5 + T cells are likely due to the reduced expression of CCL5.
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