Validating large language models against manual information extraction from case reports of drug-induced parkinsonism in patients with schizophrenia spectrum and mood disorders: a proof of concept study.

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Tác giả: Alina Glück, Dusan Hirjak, Andreas Meyer-Lindenberg, Emanuel Schwarz, Sebastian Volkmer

Ngôn ngữ: eng

Ký hiệu phân loại:

Thông tin xuất bản: Germany : Schizophrenia (Heidelberg, Germany) , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 727810

In this proof of concept study, we demonstrated how Large Language Models (LLMs) can automate the conversion of unstructured case reports into clinical ratings. By leveraging instructions from a standardized clinical rating scale and evaluating the LLM's confidence in its outputs, we aimed to refine prompting strategies and enhance reproducibility. Using this strategy and case reports of drug-induced Parkinsonism, we showed that LLM-extracted data closely align with clinical rater manual extraction, achieving an accuracy of 90%.
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