Various types of embolic substances are used in endovascular therapy, and understanding their characteristics, including shape and kinetics, is essential for proper use. Cyanoacrylate is a typical liquid embolization agent that can be applied to many cerebral neurovascular lesions. It is injected as a mixture with ethiodized oil to provide radiopacity and regulate the polymerization rate. This review describes the characteristics, action mechanisms, techniques of use, and potential pitfalls of using cyanoacrylate-ethiodized oil mixtures for embolization.