Maternal stress exposure during pregnancy is known to affect offspring behavior, including learning and memory. We hypothesized that maternal stress-induced changes transmit this effect through maternal line mediated transgenerational epigenetic inheritance. To test our hypothesis, pregnant rats (F0) were undisturbed (Control, Ctrl)/exposed to social stress during gestational days (GD) 16-18 (PMS)/exposed to social stress and treated with oxytocin during GD-16 to 18 (PMS+OXT). Subsequently, F1 female offspring from Ctrl, PMS, and PMS+OXT were mated with Ctrl F1 males to examine maternal line mediated transgenerational impacts. Female animals (F1 and F2) were subjected to behavioral test and the levels of global H3K4me2/H3K4me3 methylation, methylation in the CRH promoter, expression of