Charting New Territory With a Novel WHO Provisional Category: A Case Study of a Low-Grade Oncocytic Tumor (LOT) in the Kidney.

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Tác giả: Jayalakshmi N Alagar, Samir M Amer, Binyam Fentaw, Kassaye Firde, Daniela Proca, Anjali Seth

Ngôn ngữ: eng

Ký hiệu phân loại: 133.542 Casting horoscopes

Thông tin xuất bản: United States : Cureus , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 728122

A low-grade oncocytic tumor of the kidney (LOT) is a distinctive entity categorized under the 2022 World Health Organization (WHO) classification as "Other oncocytic tumors of the kidney." It represents a unique subset of oncocytic tumors, distinct from oncocytoma and chromophobe renal cell carcinoma. Characterized by bland oncocytic cells that diffusely express CK7 and lack CD117 expression, LOT typically manifests as a solitary, small lesion with a low stage. Available data suggest that LOT follows an indolent clinical course. Herein, we present a case of LOT in a 64-year-old male with a favorable course at a one-year follow-up. Understanding the clinical, morphological, and immunophenotypic features of LOT is paramount for accurate identification and characterization. This knowledge facilitates more conservative surgical and clinical management, optimizing patient care and outcomes.
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