Targeting Lysophosphatidic Acid Ameliorates Dyslipidemia in Familial Hypercholesterolemia.

• Tác giả: Yunhui Du, Zhiyong Du, Xiaoqian Gao, Lijie Han, Chaowei Hu, Fan Li, Jianping Li, Linyi Li, Yanwen Qin, Haili Sun, Xuechun Sun, Luya Wang, Yu Wang, Jingci Xing, Huahui Yu, Zihan Zhang
• Ngôn ngữ: eng
• Thông tin xuất bản: United States : Research (Washington, D.C.) , 2025
• Bộ sưu tập: NCBI
• ID: 728206

Tóm tắt

 Familial hypercholesterolemia (FH) is a lipoprotein disorder characterized by elevated plasma levels of low-density lipoprotein cholesterol (LDL-C) and an increased risk of premature atherosclerotic cardiovascular disease. Recent evidences have shown that several glycerophospholipid species were markedly altered in experimental FH animals and exhibited diverse bioactivities. Nevertheless, the glycerophospholipid profiles and their associated biological implications in human FH remain largely unknown. In this study, we sought to comprehensively delineate the glycerophospholipid phenotypes in human FH and to investigate the functional roles of key FH-altered glycerophospholipid molecules on cholesterol metabolism. Targeted analysis of 328 glycerophospholipid metabolites was used to profile the differentiated alterations in patients with homozygous FH (HoFH