Design and synthesis of 3-(azepan-1-ylsulfonyl)-

• Tác giả: Mohammad A Khanfar, Mohammad Saleh
• Ngôn ngữ: eng
• Ký hiệu phân loại: 005.754 Network databases
• Thông tin xuất bản: Germany : Zeitschrift fur Naturforschung. C, Journal of biosciences , 2025
• Bộ sưu tập: NCBI
• ID: 728325

Tóm tắt

Carbonic anhydrase IX (CAIX) is known to be overexpressed in various tumors and plays a significant role in tumor development and progression. A series of 3-sulfonamide benzoate derivatives with a 7-membered azepane ring were synthesized and evaluated for their CAIX inhibitory activities. Most of the synthesized compounds successfully inhibited CAIX activities, exhibiting IC