New solutions for antibiotic discovery: Prioritizing microbial biosynthetic space using ecology and machine learning.

• Tác giả: Marnix H Medema, Gilles P van Wezel
• Ngôn ngữ: eng
• Thông tin xuất bản: United States : PLoS biology , 2025
• Bộ sưu tập: NCBI
• ID: 728337

Tóm tắt

With the explosive increase in genome sequence data, perhaps the major challenge in natural-product-based drug discovery is the identification of gene clusters most likely to specify new chemistry and bioactivities. We discuss the challenges and state-of-the-art of antibiotic discovery based on ecological principles, genome mining and artificial intelligence.