Adeno-associated viral delivery of Env-specific antibodies prevents SIV rebound after discontinuing antiretroviral therapy.

• Tác giả: Aimee Broman, Saverio Capuano, Natasha M Clark, David T Evans, Christine M Fennessey, Guangping Gao, Matthew R Gardner, Taina T Immonen, Brandon F Keele, Nida K Keles, Vadim A Klenchin, Emek Kose, Jeffrey D Lifson, Rosemarie Mason, Mario Roederer
• Ngôn ngữ: eng
• Thông tin xuất bản: United States : Science immunology , 2025
• Bộ sưu tập: NCBI
• ID: 728497

Tóm tắt

An alternative to lifelong antiretroviral therapy (ART) is needed to achieve durable control of HIV-1. Here, we show that adeno-associated virus (AAV) delivery of two rhesus macaque antibodies to the simian immunodeficiency virus (SIV) envelope glycoprotein (Env) with potent neutralization and antibody-dependent cellular cytotoxicity can prevent viral rebound in macaques infected with barcoded SIV