INTRODUCTION: Autism Spectrum Disorders (ASD) and Obsessive Compulsive Disorders (OCD) can be confused with each other but can also occur together, presenting a more severe clinical picture with a worse response to typical OCD treatment. OBJECTIVE: We review the current situation on the topic, the specific characteristics of both disorders, the implication of the changes to the DSM-5-TR, their evaluation and approach. CONCLUSIONS: ASD-OCD comorbidity presents atypicalities that require a detailed evaluation and adapted treatments.