Autism is a neurodevelopmental disorder with a neurobiological basis characterized by deficits in social cognition and communication, restricted interests and stereotyped behaviors. It is frequently associated with sensory dysfunctions, other neurodevelopmental disorders, neuropsychiatric disorders, epilepsy and/or sleep disorders. This condition will accompany people throughout their lives, which will generate various needs for support and treatments. This spectrum of social, cognitive, communication, neuropsychiatric and clinical dysfunctions means that people with autism are subjected to great social pressure to meet expectations and relate appropriately, which can lead to great fatigue with consequences such as exhaustion (burnout) that can affect their physical and mental health and increase social withdrawal. Additionally, exhaustion can occur in the family, teachers and therapists with serious commitment to physical and mental health and in the workplace. Although burnout is a very present topic in the autistic community, it is rarely addressed in professional settings. In this paper I will address burnout in autistic people, their families, teachers and professionals by analyzing its triggers, clinical manifestations and prevention or mitigation.