Iridium-Catalyzed Asymmetric Allylation of Silyl Enol Ethers Derived from α-Ketoesters and α-Diketones with Allylic Alcohols.

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Tác giả: Yuta Goto, Kazunori Miyashita, Takahiro Sawano, Natsuki Suzuki, Kana Takahashi, Ryo Takeuchi

Ngôn ngữ: eng

Ký hiệu phân loại:

Thông tin xuất bản: United States : Organic letters , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 728607

We report an asymmetric allylation of silyl enol ethers derived from α-ketoesters with allylic alcohols by an iridium/chiral (P,olefin)-ligand catalyst. Allylation with a broad range of silyl enol ethers and allylic alcohols formed the allylated products with excellent enantioselectivities. Silyl enol ethers derived from α-diketones as well as α-ketoesters were also compatible with the asymmetric allylation to achieve nearly perfect enantioselectivities. The utility of allylated products bearing an α-ketoester group and an α-diketone group is demonstrated by transformation to valuable functional groups, exemplified by α-aminoester, aldehyde, 2(1
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