PURPOSE: To provide a robust whole-brain quantitative magnetization transfer (MT) imaging method that is not limited by long acquisition times. METHODS: Two variants of a spiral 2D interleaved multi-slice spoiled gradient echo (SPGR) sequence are used for rapid quantitative MT imaging of the brain at 3 T. A dual flip angle, steady-state prepared, double-contrast method is used for combined B RESULTS: Whole-brain quantitative MT imaging was feasible for all sets with total acquisition times ranging from 7:15 min down to 3:15 min. For accurate modeling, B CONCLUSION: The combination of rapid B