The role of fetal hemoglobin in the artificial placenta: A premature ovine model.

• Tác giả: Robert H Bartlett, Marie Cornell, Brian P Fallon, Ronald B Hirschl, David M Manthei, Jennifer S McLeod, George B Mychaliska, Erin E Perrone, Alvaro Rojas-Peña, Brianna L Spencer
• Ngôn ngữ: eng
• Thông tin xuất bản: England : Perfusion , 2025
• Bộ sưu tập: NCBI
• ID: 728790

Tóm tắt

INTRODUCTION: A radical paradigm shift in the treatment of premature infants failing conventional treatment is to recreate fetal physiology using an extracorporeal Artificial Placenta (AP). The aim of this study is to evaluate the effects of changing fetal hemoglobin percent (HbF%) on physiology and circuit function during AP support in an ovine model. METHODS: Extremely premature lambs ( RESULTS: The mean survival time on circuit was 119.6 ± 39.5 h. Hemodynamic parameters and lactate were stable throughout. As more adult blood transfusions were given to maintain hemoglobin at 10 mg/dL, the HbF% declined, reaching 40% by post operative day 7. The HbF% was inversely proportional to flow rates as higher flows were required to maintain adequate oxygen saturation and perfusion. CONCLUSIONS: Transfusion of adult blood led to decreased fetal hemoglobin concentration during AP support. The HbF% was inversely proportional to flow rates. Future directions include strategies to decrease the priming volume and establishing a fetal blood bank to have blood rich in HbF.