Assessment of the Therapeutic Effectiveness of Glutathione-Enhanced Mesenchymal Stem Cells in Rat Models of Chronic Bladder Ischemia-Induced Overactive Bladder and Detrusor Underactivity.

• Tác giả: Myung-Soo Choo, Hyungu Kwon, Chae-Min Ryu, Dong-Myung Shin, Jung Hyun Shin, Hwan Yeul Yu, Hong Duck Yun
• Ngôn ngữ: eng
• Thông tin xuất bản: Korea (South) : International journal of stem cells , 2025
• Bộ sưu tập: NCBI
• ID: 728813

Tóm tắt

 Overactive bladder (OAB) and detrusor underactivity (DUA) are representative voiding dysfunctions with a chronic nature and limited treatment modalities, and are ideal targets for stem cell therapy. In the present study, we investigated the therapeutic efficacy of human mesenchymal stem cells (MSCs) with a high antioxidant capacity generated by the Primed Fresh OCT4 (PFO) procedure in chronic bladder ischemia (CBI)-induced OAB and DUA rat models. Sixteen-week-old male Sprague-Dawley rats were divided into three groups (sham, OAB or DUA, and stem cell groups
  n=10, respectively). CBI was induced by bilateral iliac arterial injury (OAB, 10 times
  DUA, 30 times) followed by a 1.25% cholesterol diet for 8 weeks. Seven weeks after injury, rats in the stem cell and other groups were injected with 1╳10