Lung Cancer Organoid System to Evaluate the Cytotoxicity of Natural Killer Cells.

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Tác giả: Youngtae Jeong, Jeongmin Kim, Namwoog Kim, Byungmoo Oh

Ngôn ngữ: eng

Ký hiệu phân loại:

Thông tin xuất bản: Korea (South) : International journal of stem cells , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 728874

Natural killer (NK) cells are gaining growing attention due to their promise for immunotherapy. A fast and accurate system is needed to test NK cell biology and their therapeutic application. Here, we report a lung cancer organoid-based system to evaluate NK cells' cytotoxicity. We first established the lung cancer organoids on top of Matrigel, which allows the co-culture with NK cells. When co-cultured, NK cells moved close to and inside the lung cancer organoids. When we analyzed by flow cytometry, co-culture of NK cells induced a significantly higher ratio of cell death of lung cancer organoids, suggesting that lung cancer organoids can be employed to test the cytotoxicity of NK cells. Finally, the pre-treatment of NK cells with A83-01, a TGF
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