Cinnamaldehyde Alleviates Alveolar Epithelial Cell Injury in ALI by Inhibiting the CaMKII Pathway.

• Tác giả: Siming Chen, Wankang Dian, Lei Liu, Hao Zhang, Zhou Zheng
• Ngôn ngữ: eng
• Thông tin xuất bản: United States : Cell biochemistry and biophysics , 2025
• Bộ sưu tập: NCBI
• ID: 729172

Tóm tắt

Alveolar epithelial cell injury plays a key role in acute lung injury (ALI) and is a vital determinant of its severity. Here, we aimed to assess the protective effects of cinnamaldehyde (CA) on lipopolysaccharide (LPS)-induced A549 cells and elucidate the underlying mechanisms. A549 cells were stimulated with 1 μg/mL LPS for 24 h to establish an alveolar epithelial cell injury model and subsequently treated with CA or Ca