Exposure-Efficacy Analysis and Dopamine D2 Receptor Occupancy in Adults with Schizophrenia after Treatment with the Monthly Intramuscular Injectable Risperidone ISM.

• Tác giả: Marcos Almendros, Lourdes Anta, Ignacio Ayani, Lourdes Ochoa Díaz de Monasterioguren, Ibón Gutierro, Christian Laveille, Andreas Lindauer, Javier Martínez-González, Eric Snoeck
• Ngôn ngữ: eng
• Thông tin xuất bản: England : Journal of clinical pharmacology , 2025
• Bộ sưu tập: NCBI
• ID: 729327

Tóm tắt

Dopamine D2 receptor occupancy (D2RO) significantly influences the clinical effectiveness and safety of many antipsychotic drugs. Maintaining a D2RO range of 65%-80% provides the best antipsychotic effects while minimizing adverse reactions. Data from a Phase III trial were used to establish an exposure-response relationship for monthly intramuscular Risperidone ISM (75 and 100 mg) or placebo administered to adults with schizophrenia. Pharmacodynamic analysis was based on an E