RATIONALE AND OBJECTIVES: To investigate factors influencing the success and complication rate of percutaneous transhepatic biliary drainage (PTBD). MATERIALS AND METHODS: PTBD procedures between 2017 and 2022 were enrolled retrospectively. Success rate, complications, and technical considerations were compared using Mann-Whitney U-, X RESULTS: In 398 patients, 499 PTBD procedures (337 men
mean age 66.2 +/- 12.5 years) were carried out, with a success rate of 83.2% (415/499). PTBD in dilated bile ducts was more successful than in non-dilated bile ducts (90.0%
316/340 vs. 68.6%
109/159
p <
0.002), with e.g. lower radiation doses (2787.52 +/- 4012.72 cGy*cm CONCLUSION: Medical centers adopting PTBD procedures can potentially increase their success rate significantly within a short period of time. PTBD is a safe procedure, with left-sided approaches showing lower complication rates and radiation exposure, underscoring their often-underestimated advantages in clinical practice.