MRI evaluation of neuroprotective effects of Astragaloside Ⅳ on rotenone-induced late-stage Parkinson's disease mice.

• Tác giả: He Gong, Minglong Li, Miaomiao Liu, Quanyuan Liu, Yuwei Liu, Kai Qi, Fengjiao Sun, Hongcai Wang, Jing Wang, Mengdi Wang, Rui Wang
• Ngôn ngữ: eng
• Thông tin xuất bản: United States : Neuroscience , 2025
• Bộ sưu tập: NCBI
• ID: 730152

Tóm tắt

Astragaloside Ⅳ (AS-Ⅳ) improved the motor behavior of Parkinson's disease (PD) mouse but the alteration of imaging in the PD mice brain was unclear. PD models were established by unilateral injection of rotenone (ROT) into the substantia nigra pars compacta (SNc) of mice. AS-Ⅳ (20 mg/kg) was intraperitoneally injected once daily for 14 days. Pole and rotarod tests were performed to evaluate behavioral alterations at 32 weeks. Flow cytometry, electrophysiological recordings techniques, and MRI were performed to assess the neuroprotective effects of AS-Ⅳ. AS-Ⅳ ameliorated motor deficits and the incidence of dystonia in animal models of PD. AS-Ⅳ administration inhibited CD4