Uterus transplantation (UTx) has emerged from clinical trials and is expected to become the standard of care for uterine factor infertility. Uterus transplant candidates historically have had to meet strict eligibility criteria to participate in clinical trials. Continued application of psychologic selection criteria from clinical trial may hinder the expansion of UTx. UTx candidates come with unique mental health challenges, having a higher incidence of mental health problems than the general population. We posit in this commentary that broadening psychological inclusion criterion and provision of mental health support will enhance access to UTx. At the University of Alabama at Birmingham (UAB), candidates are not required to mention mental health comorbidities at initial screening. Regardless of their mental health comorbidity status, all recipients at the UAB have had a successful uterus transplant. Outcome of a live birth has also not been affected. Perioperative mental health challenges are successfully managed with a support of psychologists and psychiatrists.