BACKGROUND: Nutrition is a key factor limiting the rapid recovery of patients undergoing esophagectomy, but there is as yet no consensus on the optimal route of nutritional support. This study aimed to evaluate the potential benefits of laparoscopic jejunostomy (Lap-J) in comparison to conventional nasoenteral tube (NT) feeding in patients who underwent McKeown minimally invasive esophagectomy (MIE). METHODS: A total of 577 consecutive patients with esophageal squamous cell carcinoma (ESCC) who underwent McKeown MIE were included in this single-center retrospective study. They were divided into two groups based on whether or not an intraoperative jejunostomy tube (JT) was placed, and baseline information was made consistent between the 2 groups using propensity score matching (PSM). RESULTS: After exclusion and matching, 149 patients were included in each of the 2 groups. Compared with NT, patients who received JT had a shorter postoperative length of stay (11d vs 9d, P = 0.002), lower perioperative albumin loss rate (0.17 vs 0.13, P = 0.023), and lower rates of postoperative pneumonia (23 vs 3, P <
0.002) and pleural effusion (16 vs 5, P = 0.027). There was no significant difference in the occurrence of anastomotic leakage (AL) between the 2 groups. But in the group of patients with AL, the jejunostomy group had a significantly lower rate of perioperative albumin loss (0.20 (0.14-0.26) vs 0.12 (0.08-0.16) P = 0.03) and readmission (8 (40.0) vs. 2 (7.4) P = 0.019). CONCLUSIONS: Lap-J during the McKeown MIE has demonstrated good safety and feasibility, and it contributes to the recovery of AL, making its outcome safe and simple. TRIAL REGISTRATION: National clinical trials registry: NCT06192212, registered January 4th, 2024.