Association of the skin microbiome with the biomechanical scar properties in patients with burns.

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Tác giả: Yoon Soo Cho, So Young Joo, Yeongyun Jung, Minseok Kim, Huseong Lee, Seung Tae Lee, Cheolju Park, Cheong Hoon Seo, Jung Im Yun

Ngôn ngữ: eng

Ký hiệu phân loại:

Thông tin xuất bản: Netherlands : Burns : journal of the International Society for Burn Injuries , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 730635

 BACKGROUND AND OBJECTIVES: Skin microbiome dysbiosis can cause skin barrier dysfunction and stimulate scar property change. Skin barrier disruption post-burn injury leads to an imbalance in skin microbe diversity and distribution. We aimed to examine the changes in the skin microbiome of re-epithelialized burn scars. MATERIAL AND METHODS: Twenty three patients were enrolled between January 2020 and July 2022. Twenty-six (13 Scar 1, immediately after complete wound healing
  and 13 Scar 2, 3 months after complete wound healing) of seventy-eight scar skin samples (39 Scar 1 and 39 scar 2) qualified for analysis. Microbial community analysis was performed. Biomechanical scar properties of each patient and their correlation with skin microbiome were investigated. RESULTS: The α-diversity of the scarred skin microbiome increased with time (Shannon's index, p = 0.029
  Simpson's index, p = 0.009). The linear discriminant analysis effect size results showed that Bacteroides abundance decreased in scars after 3 months, whereas Campylobacter and Cutibacterium abundance increased. Campylobacter and Cutibacterium negatively and positively correlated with the final distensibility gross and biological elasticity, respectively. These results were consistent with the changes in the biomechanical properties of scars. CONCLUSION: The scar skin microbial communities in patients with burns changed with biomechanical scar properties over time, and specific skin microorganisms correlated with biomechanical scar dynamics at the genus level.
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