Global metabolomic alterations associated with endocrine-disrupting chemicals among pregnant individuals and newborns.

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Tác giả: Ariel Alexander, Priyanka Bhashyam, Julianne C Botelho, Joseph M Braun, Antonia M Calafat, Aimin Chen, Emily A DeFranco, Shuk-Mei Ho, Shouxiong Huang, Dean P Jones, Dasom V Kim, Stephani S Kim, Raymund Lee, Yuet-Kin Leung, Kathrine E Manz, Kurt D Pennell, Zana Percy, Jagadeesh Puvvula, Lucie C Song, Vilinh Tran, Ann M Vuong, Klaudia J Zalewska

Ngôn ngữ: eng

Ký hiệu phân loại:

Thông tin xuất bản: United States : Metabolomics : Official journal of the Metabolomic Society , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 730796

 BACKGROUND: Gestational exposure to non-persistent endocrine-disrupting chemicals (EDCs) may be associated with adverse pregnancy outcomes. While many EDCs affect the endocrine system, their effects on endocrine-related metabolic pathways remain unclear. This study aims to explore the global metabolome changes associated with EDC biomarkers at delivery. METHODS: This study included 75 pregnant individuals who delivered at the University of Cincinnati Hospital from 2014 to 2017. We measured maternal urinary biomarkers of paraben/phenol (12), phthalate (13), and phthalate replacements (4) from the samples collected during the delivery visit. Global serum metabolome profiles were analyzed from maternal blood (n = 72) and newborn (n = 63) cord blood samples collected at delivery. Fifteen of the 29 urinary biomarkers were excluded due to low detection frequency or potential exposures during hospital stay. We assessed metabolome-wide associations between 14 maternal urinary biomarkers and maternal/newborn metabolome profiles. Additionally, performed enrichment analysis to identify potential alterations in metabolic pathways. RESULTS: We observed metabolome-wide associations between maternal urinary concentrations of phthalate metabolites (mono-isobutyl phthalate), phthalate replacements (mono-2-ethyl-5-carboxypentyl terephthalate, mono-2-ethyl-5-hydroxyhexyl terephthalate) and phenols (bisphenol-A, bisphenol-S) and maternal serum metabolome, using q-value <
  0.2 as a threshold. Additionally, associations of phthalate metabolites (mono-n-butyl phthalate, monobenzyl phthalate) and phenols (2,5-dichlorophenol, BPA) with the newborn metabolome were noted. Enrichment analyses revealed associations (p-gamma <
  0.05) with amino acid, carbohydrate, lipid, glycan, vitamin, and other cofactor metabolism pathways. CONCLUSION: Maternal paraben, phenol, phthalate, and phthalate replacement biomarker concentrations at delivery were associated with maternal and newborn serum global metabolome.
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