A-D-A type fluorescent probe with dual quaternary-ammonium-salt anchors for turn on detection of HSA in wide emission gamut.

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Tác giả: Ying Bao, Wenling Huang, Na Jiang, Yuedan Luo, Xinyu Lv, Yi Qu, Chao Shang, Le Wang, Wancheng Zou

Ngôn ngữ: eng

Ký hiệu phân loại:

Thông tin xuất bản: England : Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 730799

Human serum albumin (HSA) is a key protein implicates in various physiological and pathological conditions such as renal injury, diabetes mellitus. Herein, we report an AIE-active fluorescent probe (DNI-4) for detection of HSA with a "turn on" response covering visible and near-infrared region (500 - 800 nm). Combining with a triphenylamine and two 1,8-naphthalimide moieties, the chromophore segment of DNI-4 forms a "A-D-A" type molecular architecture with the twisted intramolecular charge transfer property. Two quaternary ammonium salt moieties are introduced into the chromophore to give the probe (DNI-4), which has good hydrophilicity and can interact with HSA to form the dye-HSA aggregates with "turn-on" signal. DNI-4 demonstrates a good linear correlation over a low concentration range of HSA from 0 to 0.2 μM (R
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