Method Development and Clinical Utility for Simultaneous Measurement of 21-Deoxycortisol, 17-Hydroxyprogesterone, Cortisol, and Cortisone Levels in Human Plasma Using UHPLC-MS/MS.

• Tác giả: Ali Al-Odaib, Syed N Alvi, Saleh Al Dgither
• Ngôn ngữ: eng
• Ký hiệu phân loại: 338.9 Economic development and growth
• Thông tin xuất bản: United States : Advances in pharmacological and pharmaceutical sciences , 2025
• Bộ sưu tập: NCBI
• ID: 730831
• Chủ đề: 1. Method; 2. Development; 3. And

Tóm tắt

A simple and efficient validated assay for quantifying 21-deoxycortisol (21-DOC), 17-hydroxyprogesterone (17-OHP), cortisol, and cortisone in human plasma has been developed using ultra-high performance liquid chromatography coupled with tandem mass spectrometry (UHPLC-MS/MS). Analysis of plasma samples were performed on Atlantis dC18 (3