Copper excess induces autophagy dysfunction and mitochondrial ROS-ferroptosis progression, inhibits cellular biosynthesis of milk protein and lipid in bovine mammary epithelial cells.

• Tác giả: Jun Hao Cui, Ya Ting Fan, Yong Cheng Jin, Dong Qiao Peng, Jing Lin Shen, Xin Yue Yang, Jin Ge Zhang
• Ngôn ngữ: eng
• Thông tin xuất bản: Netherlands : Ecotoxicology and environmental safety , 2025
• Bộ sưu tập: NCBI
• ID: 730946

Tóm tắt

 Excessive copper (Cu) has the potential risk to ecosystems and organism health, with its impact on dairy cow mammary glands being not well-defined. This study used a bovine mammary epithelial cell (MAC-T) model to explore how copper excess affects cellular oxidative stress, autophagy, ferroptosis, and protein and lipid biosynthesis in milk. Results showed the increased intracellular ROS, MDA, and CAT (P <
  0.05), alongside decreased T-SOD and GSH in CuSO