One-step engineered mesenchymal stem cell-derived exosomes against hepatic ischemia-reperfusion injury.

• Tác giả: Jun Chen, Haijun Guo, Haitao Hu, Xinfeng Lu, Nasha Qiu, Yuhao Ren, Zile Shao, Yiyang Sun, Lin Tang, Chang Xie, Xiao Xu, Hui Zhang, Yujie Zhou
• Ngôn ngữ: eng
• Thông tin xuất bản: Netherlands : International journal of pharmaceutics , 2025
• Bộ sưu tập: NCBI
• ID: 731161

Tóm tắt

Hepatic ischemia-reperfusion injury (IRI) is an important factor affecting the prognosis of patients undergoing surgery. Exosomes derived from mesenchymal stem cells (MSC-EXOs) are widely used and play a therapeutic role in hepatic IRI. However, natural exosomes lack liver-targeting ability and have low bioavailability. In this study, MSC-EXOs were simply modified with OPDEA-PCL or liver-targeting DSPE-PEG