Simultaneous co-delivery of both antigens and adjuvants is crucial for the efficient activation of dendritic cells (DCs), but it has often been overlooked in the context of tumor cell-based vaccines. Building on the significant advancements in cationic nano-adjuvants, we proposed a straightforward and effective strategy for crafting personalized cancer vaccines, in which tumor cell vesicle antigens were paired with cationic nano-adjuvants to form nano-network through electrostatic adherence. Our pioneering research indicates that densely arranged nanoparticles can be simultaneously taken up by DCs, thus facilitating the co-delivery of adjuvants and antigens. To further enhance the interaction between DCs and antigens, the antigens-adjuvants nano-network was reconstructed using high aspect ratio silicon dioxide (SiO