Electrochemical and computational studies on the interaction between calf-thymus DNA and skin whitening agent arbutin.

• Tác giả: Dilek Eskiköy Bayraktepe, Alper Fitoz, Maryam M M Mahdi, Zehra Yazan, Ceren Yıldız
• Ngôn ngữ: eng
• Thông tin xuất bản: Netherlands : Bioelectrochemistry (Amsterdam, Netherlands) , 2025
• Bộ sưu tập: NCBI
• ID: 731185

Tóm tắt

The interaction between double-stranded calf thymus DNA (ctDNA) and the skin whitening agent arbutin (AR) examined by applying electrochemical and computational methods for the first time in literature. A single-use pencil graphite electrode via cyclic (CV) and differential pulse voltammetry (DPV) techniques were applied to determine the kinetic and thermodynamic parameters in the absence and presence of ctDNA. To examine the interaction process, oxidation peak currents and potentials of AR were observed prior to the addition of various ctDNA concentrations. The binding constants (K