The association between estrogenic activity evolution and the formation of different products during the photochemical transformation of parabens in water.

• Tác giả: Taicheng An, Guanhui Chen, Yanpeng Gao, Xinping Hui, Guiying Li, Na Luo, Mei Ma, Xiaolin Niu, Mei Wang
• Ngôn ngữ: eng
• Thông tin xuất bản: England : Water research , 2025
• Bộ sưu tập: NCBI
• ID: 731342

Tóm tắt

 Photochemical transformation is a critical factor influencing the environmental fate of pharmaceutical and personal care products in aquatic ecosystems. However, the relationship between toxicity evolution and the formation of various transformation products has been seldom explored. This study investigates the behavior and changes in estrogenic activity during the photochemical transformation of a series of typical endocrine-disrupting parabens (PBs), focusing on the effects of increasing alkyl-chain length (MPB, EPB, PPB and BPB). Based on MS/MS analysis, four types of transformation products were identified: (1) p-hydroxybenzoic acid (HB), which exhibits no estrogenic activity
  (2) hydroxylated products (OH-PBs)
  (3) dimer products formed between HB and PBs (HB-PBs)
  and (4) dimer products formed from identical PBs (PBs-PBs), comprising three distinct isomers. In the absence of standard sample, OH-PBs were synthesized and their estrogenic activity was evaluated using a yeast two-hybrid reporter assay. The EC